What is Down Syndrome? Down Syndrome is when an individual has an extra chromosome, not just any chromosome, but one of the happiest chromosomes. The extra chromosome gives you that extra laugh in your day. They have the ability to laugh and find humor in things that many may be too busy to see. Most people think or feel that being Down Syndrome is a bad thing, but Down Syndrome makes you different, like awesome different, fun different, and happy different. Truth is everybody is different, yet everybody is more alike than they realize. Being Down Syndrome makes you learn that other people's differences shine in a different and new way!